The 2018 Medicinal Chemistry Gordon Research Conference will feature talks on the cutting edge of the discipline that include new innovations, technologies and compounds that advance the science. Robert Marquis of GlaxoSmithKline is responsible for the scientific program; please see the planned topic areas below and contact the Chairs if you would like to submit a talk proposal. The program of speakers will be developed between August and November, 2017. In addition to the general scientific sessions the conference will culminate with a Special Topics Session organized by Joshi Ramanjulu of GlaxoSmithKline. This session comprises late-breaking results on important clinical candidates across therapeutic areas. Finally, the conference will wrap up on Thursday evening with the Keynote address organized by the Chair. We strongly encourage attendees to submit poster presentations on any aspect of Medicinal Chemistry as, historically, the poster sessions have been an essential outlet for thoughtful discussion and interaction among the conferees. This year, the poster sessions will be organized by Michael Pollastri of Northeastern University. This conference is typically full by early May. We encourage application by April 1st and the submission of any poster abstracts by April 15th to facilitate the admissions process. The 2018 Medicinal Chemistry GRC will continue a tradition of outstanding science presented in a relaxed atmosphere offering a variety of social activities. Vice-Chair Elect Janeta Popovici-Muller of Decibel Therapeutics will organize social events for the week, including hikes of Mt. Kearsarge and Mt. Cardigan, the Philbrick-Cricenti bog walk, frisbee golf, volleyball, softball, soccer, a golf scramble, and a charity poker tournament. As we look forward to another outstanding conference in 2018, on behalf of myself, the Vice Chair and the Vice-Chair elect, we welcome your application and particularly encourage the application from those of diverse scientific backgrounds.